AdenomyosisBackground: Adenomyosis is a benign gynecologic condition characterized by the ectopic growth of endometrial tissue in the myometrium [1]. Adenomyosis presents with symptoms of dysmenorrhea (painful periods), dyspareunia (pain with sex), and abnormal uterine bleeding, which have been shown to decrease global quality of life (QOL) as well as sexual quality of life in women [2,3]. The prevalence of adenomyosis ranges between 16-62% among women undergoing hysterectomy or other surgery [2].
Adenomyosis is severely understudied because diagnosis requires a hysterectomy for histopathological diagnosis [1]. Adenomyosis is also associated with infertility, as well as several adverse gynecologic outcomes such as endometriosis and pelvic pain [2-4]. |
Graphical Abstract. Non-invasive sampling combined with immunometabolic profiling for adenomyosis detection. Lorentzen GM, Laniewski P, Cui H, Roe DJ, Mourad J, Mahnert ND, Farland LV, Herbst-Kralovetz MM. Immunometabolic profiling of cervicovaginal lavages identifies key signatures associated with adenomyosis. iScience. 2022 Nov 4;25(12):105508. doi: 10.1016/j.isci.2022.105508. PMID: 36419846. |
Projects
Related Projects: A study in the lab has applied immunometabolic profiling as a non-invasive diagnostic tool for adenomyosis. Ongoing projects are focused on investigating adenomyosis and the microbiome, as well as quality of life in patients with adenomyosis.
Published Studies:
Published Studies:
- Lorentzen GM, Laniewski P, Cui H, Roe DJ, Mourad J, Mahnert ND, Farland LV, Herbst-Kralovetz MM. Immunometabolic profiling of cervicovaginal lavages identifies key signatures associated with adenomyosis. iScience. 2022 Nov 4;25(12):105508. doi: 10.1016/j.isci.2022.105508. PMID: 36419846
Endometriosis
Background: Endometriosis is a benign gynecological condition characterized by endometrial-like tissue growing outside of the uterus [5]. The prevalence of endometriosis is higher in developing countries including Australia, Canada, and the United States [6,7]. In the United States, more than 1 in 10 women have endometriosis [5]. Endometriosis is associated with other gynecologic conditions such as infertility and chronic pelvic pain [8,9]. Although endometriosis research efforts have recently increased, limited information exists on the pathophysiology, progression, and prognosis of endometriosis [10].
Gut dysbiosis negatively impacts the estrobolome. Salliss ME, Farland LV, Mahnert ND, Herbst-Kralovetz MM. The role of gut and genital microbiota and the estrobolome in endometriosis, infertility, and chronic pelvic pain. Hum Reprod Update. 2021. 28(1):92-131. PMID: 34718567
Projects
Related Projects: A study in the lab has focused on the relationship between the microbiome and endometriosis, infertility, and chronic pelvic pain and synthesized available data on the microbiome concerning endometriosis and its related symptoms. Current research projects in the lab are investigating the role of the gut and vaginal microbiomes on endometriosis.
Published Studies
Published Studies
- Salliss ME, Farland LV, Mahnert ND, Herbst-Kralovetz MM. The role of gut and genital microbiota and the estrobolome in endometriosis, infertility, and chronic pelvic pain. Hum Reprod Update. 2021. 28(1):92-131. PMID: 34718567
- Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017. PMID: 28778332
Sources
[1] Taran FA, Stewart EA, Brucker S. Adenomyosis: Epidemiology, Risk Factors, Clinical Phenotype and Surgical and Interventional Alternatives to Hysterectomy. Geburtshilfe Frauenheilkd. 2013;73(9):924-931. doi:10.1055/s-0033-1350840 [2] Upson K, Missmer SA. Epidemiology of Adenomyosis. Semin Reprod Med. 2020;38(2-03):89-107. doi:10.1055/s-0040-1718920
[3] Alcalde AM, Martínez-Zamora MÁ, Gracia M, Ros C, Rius M, Carmona F. Assessment of quality of sexual life in women with adenomyosis. Women Health [Internet]. 2021 Jul;61(6):520–526. Available from: http://dx.doi.org/10.1080/03630242.2021.1920557 PMID: 34006207
[4] Pados G, Gordts S, Sorrentino F, Nisolle M, Nappi L, Daniilidis A. Adenomyosis and Infertility: A Literature Review. Medicina (Kaunas). 2023;59(9):1551. Published 2023 Aug 26. doi:10.3390/medicina59091551
[5] Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, Diagnosis and Clinical Management. Curr Obstet Gynecol Rep. 2017;6(1):34-41. doi:10.1007/s13669-017-0187-1
[6]Moradi Y, Shams-Beyranvand M, Khateri S, et al. A systematic review on the prevalence of endometriosis in women. Indian Journal of Medical Research. 2021;154(3):446. doi:10.4103/ijmr.IJMR_817_18
[7] Rowlands IJ, Abbott JA, Montgomery GW, Hockey R, Rogers P, Mishra GD. Prevalence and incidence of endometriosis in Australian women: a data linkage cohort study. BJOG. 2021;128(4):657-665. doi:10.1111/1471-0528.16447
[8] Bulletti C, Coccia ME, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010;27(8):441-447. doi:10.1007/s10815-010-9436-1
[9] Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39(4):535-549. doi:10.1016/j.ogc.2012.10.002
[10] Simoens S, Dunselman G, Dirksen C, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292-1299. doi:10.1093/humrep/des073
[3] Alcalde AM, Martínez-Zamora MÁ, Gracia M, Ros C, Rius M, Carmona F. Assessment of quality of sexual life in women with adenomyosis. Women Health [Internet]. 2021 Jul;61(6):520–526. Available from: http://dx.doi.org/10.1080/03630242.2021.1920557 PMID: 34006207
[4] Pados G, Gordts S, Sorrentino F, Nisolle M, Nappi L, Daniilidis A. Adenomyosis and Infertility: A Literature Review. Medicina (Kaunas). 2023;59(9):1551. Published 2023 Aug 26. doi:10.3390/medicina59091551
[5] Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, Diagnosis and Clinical Management. Curr Obstet Gynecol Rep. 2017;6(1):34-41. doi:10.1007/s13669-017-0187-1
[6]Moradi Y, Shams-Beyranvand M, Khateri S, et al. A systematic review on the prevalence of endometriosis in women. Indian Journal of Medical Research. 2021;154(3):446. doi:10.4103/ijmr.IJMR_817_18
[7] Rowlands IJ, Abbott JA, Montgomery GW, Hockey R, Rogers P, Mishra GD. Prevalence and incidence of endometriosis in Australian women: a data linkage cohort study. BJOG. 2021;128(4):657-665. doi:10.1111/1471-0528.16447
[8] Bulletti C, Coccia ME, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010;27(8):441-447. doi:10.1007/s10815-010-9436-1
[9] Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39(4):535-549. doi:10.1016/j.ogc.2012.10.002
[10] Simoens S, Dunselman G, Dirksen C, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292-1299. doi:10.1093/humrep/des073