"To positively impact women's health through the rigorous pursuit of research with high translational value"
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The Herbst-Kralovetz research lab is broadly interested in understanding innate mucosal immune responses to resident bacteria, STI pathogens (e.g HPV, HSV), and microbial products at mucosal sites, including the female reproductive tract. Dr. Herbst-Kralovetz has a long-standing interest and background in studying infections and diseases that impact in women’s health. Our lab is currently studying the relationship between vaginal dysbiosis and HPV persistence, progression and carcinogenesis, endometrial cancer and other gynecologic sequelae. The mucosa provides a major immune barrier (physical, biological, and chemical) to microbial insult and the lab is interested in studying the mucosal barrier function of the female reproductive tract and its role in host defense against infection and inflammation as well as maintaining mucosal homeostasis. Furthermore, our laboratory is investigating the mechanisms by which vaginal bacteria may influence the hallmarks of cancer.
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Research
The Herbst-Kralovetz lab utilizes a well-characterized, innovative 3-D human epithelial model system, in vivo studies and clinical samples to study host-microbe interactions in the female reproductive tract epithelium.
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Publications
Recent publications from the Herbst-Kralovetz lab highlight the complex interplay between host and microbes in the female reproductive tract as they relate to women's health.
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Team
The Herbst-Kralovetz lab is composed of an interdisciplinary team with experience in bacteriology, virology, bioinformatics and molecular/cellular biology.
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News
See the latest news updates from the Herbst-Kralovetz lab.
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